脑血管病发生风险与同型半胱氨酸的相关性研究

刘东玲.脑血管病发生风险与同型半胱氨酸的相关性研究[J].中国医师进修杂志,2013,36(10):34-36.

脑出血 脑梗塞 同型半胱氨酸

刘东玲

257500,山东省垦利县人民医院神经内科

2013

34-36.

万方

目的 探讨脑血管病发生风险与同型半胱氨酸的相关性.方法 选取经CT证实为脑血管病患者100例,其中脑出血50例(脑出血组),脑梗死50例(脑梗死组),同时选取80例健康体检者(对照组),测定所有入选者空腹血浆同型半胱氨酸(Hcy)水平；对诱发脑血管病的相关危险因素进行多元线性回归分析,观察脑血管病与Hcy的相关性.结果 脑出血组和脑梗死组血浆Hcy水平明显高于对照组(19.87±5.23)、(19.64±4.98)μmol/L比(14.54±3.58)μmol/L,P＜0.05]；脑出血组与脑梗死组血浆Hcy水平比较差异无统计学意义(P＞0.05)；对脑血管病高危因素进行多元线性回归分析显示Hcy水平与脑出血、脑梗死存在独立相关性(P＜0.01).结论 脑血管病患者血浆Hcy水平较健康人群明显升高,且Hcy与脑血管病存在独立相关性,测定血浆Hcy水平对预测及诊断脑血管病有重要意义. Objective To investigate the correlation between cerebrovascular disease risk and homocysteine (Hcy).Methods One hundred patients with cerebrovascular disease who confirmed by CT included 50 cases of cerebral hemorrhage (cerebral hemorrhage group) and 50 cases of cerebral infarction (cerebral infarction group).Eighty healthy person were selected as control group.The plasma Hcy was determined in all the subjects.The risk factors induced cerebral vascular disease were analyzed by multiple linear regression analysis and the correlation between cerebrovascular disease risk and Hcy was investigated.Results The plasma Hcy in cerebral hemorrhage group and cerebral infarction group was higher than that in control group[(19.87 ± 5.23),(19.64 ± 4.98) μ mol/L vs.(14.54 + 3.58) μ mol/L,P ＜ 0.05].There was no significant difference in the plasma Hcy between cerebral hemorrhage group and cerebral infarction group (P ＞ 0.05).Multiple linear regression analysis showed that Hcy was independently associated with cerebral hemorrhage and cerebral infarction (P ＜ 0.05).Conclusion The plasma Hcy in patients with cerebrovascular disease is higher than that in the normal population,and Hcy is independently associated with cerebrovascular disease.The plasma Hcy has an important role for prediction and diagnosis of cerebrovascular disease.