Wilson病患者神经心理特征与中医证型的相关研究

王共强，王明姝，童广安等.Wilson病患者神经心理特征与中医证型的相关研究[J].中国中西医结合杂志.2013, 33(3):318-321.

Wilson病;肝豆状核变性;神经心理;中医证型;相关性

王共强，王明姝，童广安，孙丹丹，张龙，胡文彬

安徽中医学院神经病学研究所 合肥230061

2013

318-321

知网,万方

目的 探讨Wilson病(Wilson's disease,WD)患者神经心理变化特征与中医证型的关系,为辨证论治早期干预WD神经心理功能障碍提供依据.方法 对中医辨证符合为肝胆湿热证(31例)、肝肾阴虚证(47例)和气血亏虚证(1 8例)的96例WD患者进行瑞文标准推理测验(Raven's standard progressive matrices,R'SPM)、Stroop色—字干扰测验(Stroop color-word test,CWT)及连线测验(trailmaking test,TMT)3项神经心理测验,并分析中医证型积分与3项神经心理测验成绩的相关性.结果 (1)3个中医证型的R'SPM总分、CWT-字义干扰时间、TMT-干扰量比较,差异均有统计学意义(P＜0.01,P ＜0.05).气血亏虚证的R'SPM总分、CWT-字义干扰时间与肝肾阴虚证、肝胆湿热证比较,差异均有统计学意义(P＜0.05)；气血亏虚证、肝肾阴虚证TMT-干扰量与肝胆湿热证比较,差异有统计学意义(P＜0.05).(2)3个中医证型积分均与R'SPM总分呈显著负相关(P＜0.01).肝胆湿热证积分与CWT-千扰量呈显著正相关(P＜0.01)；肝肾阴虚证积分与TMT-B项耗时数、TMT-干扰量呈显著正相关(P＜0.05)；气血亏虚证积分与CWT-字义干扰时间呈显著正相关(P＜0.05).结论 WD患者神经心理改变与中医证型具有相关性,受损程度气血亏虚证＞肝肾阴虚证＞肝胆湿热证,虚证严重程度高于实证. Objective To explore the correlation between neuropsychological features and Chi- nese medical syndrome types in Wilson's disease(WD)patients，thus providing evidence for early inter- vention by syndrome typing.Methods Totally 96 WD patients were assigned to Gan一Dan damp一heat syn- drome(GDDHS, 31 cases)，Gan-Shen yin deficiency syndrome(GSYDS, 47 cases)，and qi-blood defi- ciency syndrome(QBDS，18 cases)by syndrome typing. Three items of neuropsychological testing were performed in them，i .e，Raven's standard progressive matrices(R'SPM)，Stroop color-word test (CWT)，trail making test(TMT).The correlations between the integrals of Chinese medical syndrome types and results of the 3 tests were analyzed. Results(1)There was statistical difference in the total scores of R'SPM，the word interference time of CWT，and interference effects of TMT among the 3 syn- drome types (P