Targeting glioma stem cells via the Hedgehog signaling pathway

发表时间：2015-11-15 浏览次数：1528次

引用：

Liu Y, Liu X, Chen LC, Du WZ, Cui YQ, Piao XY, Li YL, Jiang CL. Targeting glioma

关键词：

作者：

Yang Liu, Xing Liu, Ling-Chao Chen, Wen-Zhong Du,

作者单位：

Department of Neurosurgery, The Second Affiliated

出版年份：

2014

期刊页数：

51-59

收录者：

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摘要：

Cancer is one of the leading causes of death worldwide. Gliomas are among the most devastating tumor types, and current clinical therapies are unsatisfactory. Recent reports revealed the importance of glioma-propagating cells in the malignancy of gliomas. These cells, also referred to as glioma stem cells (GSCs), share similarities with neural stem cells (NSCs). The Hedgehog (Hh) signaling pathway controls tissue polarity, patterning maintenance, and maintenance of NSCs during embryonic development. Aberrant activation of the Hh pathway resulting from mutation and deregulation has recently been recognized to cause tumorigenesis in a wide variety of tissues, including gliomas and GSCs. In this review, we explore the role of the Hh signaling pathway in GSCs and its potential as a therapeutic strategy.

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