Allogeneic epidermal substitutes in the treatment of chronic diabetic leg and foot ulcers
发表时间:2015-12-08 浏览次数:1252次
Marchesi A, Brioschi M, Parodi PC, Marchesi M, Brambilla R, Vaienti L. Allogenei
Andrea Marchesi1, Marco Brioschi1, Pier Camillo Pa
1 Department of Plastic and Reconstructive Surgery
2014
74-80
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Aim: Diabetic foot ulcers are the most common cause of nontraumatic lower extremity amputations in the industrialized world. Tissue-engineering products offer a lower extremity salvage strategy when healing does not proceed according to the standard of care. New allogeneic sheets are available for the management of diabetic leg and foot ulcers. Methods: The endpoints of this case series study regard preliminary outcomes of the application of allogeneic keratinocytes composed of benzyl ester of hyaluronic acid to 16 diabetic foot and leg ulcers in 11 patients with type 2 diabetes mellitus. Results: Between 21 and 70 days after cellular therapy, 6 out of 16 lesions were completely healed, reducing the wound dimension by 70% and improving the wound bed score by 52%. Conclusion: The clinical results of the new allogeneic sheets indicate that allogeneic keratinocytes may represent an effective and safe therapy for diabetic foot and leg ulcers in the multidisciplinary approach to this diabetes-related complication.