Nanotechnology applications in osteodistraction

发表时间：2015-12-07 浏览次数：1279次

引用：

Singleton AE, Ver Halen JP. Nanotechnology applications in osteodistraction. Pla

关键词：

作者：

Adam E Singleton1, Jon P Ver Halen2

作者单位：

1 Department of Otolaryngology-Head and Neck Surge

出版年份：

2014

期刊页数：

5-12

收录者：

其他外文数据库

摘要：

Most current strategies for bone regeneration have relatively satisfactory results. However, there are drawbacks and limitations associated with their use and availability, and even controversial reports about their efficacy and cost-effectiveness. The induction of new bone formation through distraction osteogenesis (DO) is widespread clinical application in the treatment of bone defects, limb deformities, and fracture nonunions. However, a lengthy period of external fixation is usually needed to allow the new bone to consolidate, and complications such as refracture at the distraction gap often occur. Although various biomaterials have been used as injectable delivery systems in DO models, little has been reported on the use of nanobiomaterials as carrier materials for the sustained release of growth factors in bone regeneration. One area of focus in nanotechnology is the delivery of osteogenic factors in an attempt to modulate the formation of bone. This review article seeks to demonstrate the potential of nanobiomaterials to improve biological applications pertinent to osteodistraction.

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