Wnt信号通路调控间充质干细胞成骨分化的研究进展
发表时间:2014-06-23 浏览次数:814次
陈小静,高艳虹.Wnt信号通路调控间充质干细胞成骨分化的研究进展[J].上海交通大学学报(医学版)2013, 33(1).99-103
间充质干细胞 Wnt信号通路 成骨分化 骨形成
陈小静,高艳虹
(上海交通大学医学院附属新华医院老年医学科,上海,200092)
2013
99-103
知网,万方
Wnt通路作为调控细胞生长、发育和分化的重要信号途径一直是医学研究的热点.近年来的研究表明,Wnt信号通路在调控间充质干细胞(MSCs)成骨分化过程中发挥重要作用,其机制已成为骨组织工程研究的热点,也为骨质疏松症等疾病的治疗提供了新思路.该文对Wnt信号通路调控MSCs成骨分化的研究进展进行综述. wnt signahng pathway has been thc focus of medical research as it p1ays a significant role in regulating the gro,sTth, developnlent and diffcrcntiation of cells Rcccnt studies have revealed that Wnt signaling path、 fay may play an im portant role in rcgu1ating the osteogenic dlffelentiation of mesenchymal s丨 em cdls(MsCs), tlae mechanism of which has been thc hotspot of bone tissue engincering and provides a new way for the trcatment of diseases such as osteoporosis, The research progress of Wnt signaling pathlsTay in regu1ating osteogenic differentiation of lVISCs is revicˇ `cd in this paper