不同剂量地佐辛减轻全麻拔管期心血管反应的比较

发表时间：2014-06-09 浏览次数：1202次

引用：

于向鸿；黄盛；肖剑鹏,不同剂量地佐辛减轻全麻拔管期心血管反应的比较[J].临床麻醉学杂志,2013,29(03):251-253

关键词：

全身麻醉地佐辛心血管反应

作者：

于向鸿；黄盛；肖剑鹏；

作者单位：

南京军区福州总医院麻醉科；南京军区福州总医院普通外科；南京军区福州总医院内分泌科；

出版年份：

2013

期刊页数：

251-253

收录者：

知网,万方

摘要：

比较不同剂量地佐辛对全麻术后围拔管期心血管反应的影响.方法拟在全麻下行择期腹腔镜胆囊切除术患者120例,随机均分为三组.常规麻醉后,分别在手术结束前30min静脉输洼地佐辛0.1 mg/kg(D1组)、0.2 mg/kg(D2组)和2 ml生理盐水(对照组,C组).记录手术前(基础值,T0)、缝皮结束时(T1)、拔管即刻(T2)、拔管后5 min(T3)、10 min(T4)的BP、HR及术后自主呼吸恢复时间、睁眼时间、拔管时间；记录围拔管期呼吸抑制、呛咳、拔管不良记忆、BP升高、窦性心动过速、嗜睡和术后躁动等不良反应发生率.结果与T0时比较,T2、T3时三组SBP、DBP明显升高,HR明显加快(P＜0.05)；与C组比较,T2～T4时D1、D2组SBP、DBP明显降低,HR明显减慢(P＜0.05).D2组患者自主呼吸恢复时间、睁眼时间、拔管时间延长,围拔管期呼吸抑制、嗜睡的发生率增加(P＜0.05),D1、D2组围拔管期呛咳、拔管记忆、BP升高、窦性心动过速等不良反应发生率明显降低(P＜0.05).结论静脉输注地佐辛能有效地减轻全麻手术后围拔管期心血管反应；且使用地佐辛0.1 mg/kg对呼吸影响小,能提高全麻术后的苏醒质量,更为安全. Comparison of the cardiovascular responses between different doses of decozine during general anesthesiarecovery YU Xiang-bong,HUANG Sheng.XIAO Jian-peng. Department of Anesthesiology.FuzhouGeneral Hospital of Nanjing Militar-v Commarul·Fuzhou 350025,ChinaCorresponding author:HUANG Sheng·Email:h ua ngsheng1977@ hotmail .com[Abstract] Objective To investigate the influence of different doses of decozine on attenuatingcardiovascular responses during tracheal extubation. -Methods One hundren twenty patientsundergoing elective laparoscopic cholecystectomy under general anesthesia were randomly divided intothree groups for each group. The patients received 2 ml of normal saline （group C），0. 1 mg%'kg ofintravenous decozine （group Dl）·or 0. 2 mg/kg of intravenous decozine （group D2） respectively at 30minutes before the end of surgery. BP and HR were measured at the time before surgery（To），the endof skin suture CT1），immediately before extubation（Tz），at 5 min C T）and 10 min （T}）afterextubation. The postoperative spontaneous breathing recovery time, awakening time, the extubationtime and incidence of side effects including respiratory depression, imitative cough, extubationmemory, hypertension, postoperative tachycardia,drowsiness, etc,were also recorded. Results SBP,DBP and HR of all the three groups increased significantly at T}-T3 from their respective level at ToCPGO. 05），while the values of groups Dl and D2 were significantly lower than those of group C atTz -T4（P

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