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《精神病与精神卫生学》

棕榈酸帕利哌酮和口服帕利哌酮缓释片治疗精神分裂症患者的疗效和 安全性对照研究

发表时间:2014-06-09  浏览次数:1433次

引 用:

李亚辰,李英梅,王立娜.棕榈酸帕利哌酮和口服帕利哌酮缓释片治疗精神分裂症患者的疗效和 安全性对照研究[J].吉林医学,2014,35(15).3217-321

关 键 词:

注射用棕榈酸帕利哌酮;帕利哌酮缓释片;疗效;精神分裂症

作者:

李亚辰,李英梅,王立娜

作者单位:

天津市安定医院,天津 300450

出版年份:

2014

期刊页数:

3217-3218

收录者:

知网,万方

摘要:

目的:探讨棕榈酸帕利哌酮与口服帕利哌酮缓释片治疗精神分裂症患者的疗效和安全性,为临床选择药物提供参考依据。 方法:选择76例精神分裂症患者,随机分成棕榈酸帕利哌酮(PP)组及口服帕利哌酮缓释片组,治疗时间为16周。在治疗第4周、第8 周、第12周、第16周末分别用阳性与阴性症状量表(PANSS)、不良反应量表(TESS)评定疗效和安全性。结果:两组PANSS总分4 周末开始与基线比较均显著下降(P<0.01),第4周末、第8周末组间差异有统计学意义(P<0.01)。两组的疗效相当,试验组的不 良反应发生率低于对照组,差异无统计学意义(P>0.05)。结论:棕榈酸帕利哌酮组与口服帕利哌酮缓释片组相比,治疗精神分裂症 的疗效相当,但不良反应较少。肌内注射棕榈酸帕利哌酮治疗精神分裂症是安全有效的。 Objective To investigate the treatment efficacy and safety in patients with schizophrenia using the Paliperidone Palmitate and oral Paliperidoneand,provides the reference for the clinical drug of choice.Methods 76 cases of patients with schizophrenia were randomly divided into intramuscular Paliperidone Palmitate(PP) group and the oral Paliperidone group,16 weeks of treatment.Evaluate the efficacy and adverse reactions in the treatment of 4,8,12 and 16 weeks using the Positive and Negative Syndrome Scale(PANSS),adverse reactions Scale(TESS) to assess the efficacy and safety.Results PANSS score of two groups were significantly decreased compared with baseline from 4 weekend(P<0.01),with a significant difference between the two groups at the end of the 4、8(P<0.01).the adverse reaction rate of test group was lower than the control group,but no significant difference(P>0.05).Conclusion The efficacy of Paliperidone Palmitate and oral Paliperidone Palmitate tablets in the treatment of schizophrenia is equivalent,but adverse reactions is less.Intramuscular Paliperidone Palmitate for treatment of schizophrenia is safe and effective.

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