Epithelial-mesenchymal transition in gastroenterological cancer
发表时间:2015-12-04 浏览次数:1673次
Okabe H, Mima K, Saito S, Hayashi H, Imai K, Nitta H, Hashimoto D, Chikamoto A,
Hirohisa Okabe1, Kosuke Mima1, Seiya Saito1, Hirom
1 Department of Gastroenterological Surgery, Gradu
2015
183-189
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Epithelial-mesenchymal transition (EMT) was first reported as an essential process in embryonic cells and later showed that cancer cells, regardless of the context, exhibited a similar phenomenon that was crucial for tumor progression. Epithelial cells lose their adhesive characteristic capacity which is necessary for their functions but gain a mesenchymal phenotype. This change from epithelial to the mesenchymal phenotype of cancer cells makes it difficult to understand the mechanism underlying cancer biology and tumor progression. A number of transcription factors involved in tumor cell EMT and microRNA-regulated EMT have been reported. This review discussed recent findings and new players in EMT in gastrointestinal cancers. Since the molecular mechanisms of tumor progression are sometimes context-dependent, the recent findings of EMT have been reviewed in a context-dependent manner.