核素标记受体酪氨酸激酶靶向药物显像研究进展

发表时间：2014-06-23 浏览次数：787次

引用：

张勰义,宋少莉,黄钢.核素标记受体酪氨酸激酶靶向药物显像研究进展[J].上海交通大学学报（医学版）2013, 33(1).104-108

关键词：

跨膜酪氨酸激酶受体酪氨酸激酶受体酪氨酸激酶抑制剂核素显像反应监测靶向药物

作者：

张勰义,宋少莉,黄钢

作者单位：

(上海交通大学医学院附属仁济医院核医学科,上海,200127)

出版年份：

2013

期刊页数：

104-108

收录者：

知网,万方

摘要：

跨膜受体酪氨酸激酶信号在肿瘤细胞增殖、抑制凋亡和促进新生血管形成中具有重要作用,多种恶性肿瘤过度表达该受体.随着对受体酪氨酸激酶通路的认知,已设计出众多靶向该靶点的抗肿瘤药物,如单克隆抗体、小分子酪氨酸激酶抑制剂等,临床应用证明这些药物能显著提高抗肿瘤效果,提高患者生存率.但靶向药物靶点专一、价格昂贵,早期监测靶向药物的疗效,对提供临床诊疗决策、减少药物不良反应及节约患者开支具有重要意义.核素标记受体酪氨酸激酶靶向药物显像已用于临床监测靶向药物的疗效,该文就此方面的研究进展进行综述. [Abstract]Transmembrane，repfor tycosine kinase sigpalling triggers cell proliferation, apoptosis suppression and neovasculature recruitment. Transmembrane receptor tyrosine kinases a ie 。、erelpressed in many malignancies, become the molecular targets for an number of anticancer drugs. For example, monoclonal antibodies molecule tyrosine kinase inhibitors Increasmg have been (一linically" prw ed to])lost the therapeutic effect and target and high price, and lllf',1'eaSe which have and small- survival of patients. However. the targeted drugs a I'l'(lip icall} limited by specific the early monitoring of therapeutic effects of targeted drugs is important for the design of clinical regimen and reduction of adverse effects and medical elpense The imaging of receptor tyrosine kinase targeted chugs by radionuclide has been clinically employed in the monitoring of therapeutic effects of targeted drugs, and the research twogress of this application i} reviewed in

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