类骨质羟磷灰石和自体骨修复兔下颌骨临界性骨缺损的研究
发表时间：2014-05-19 浏览次数：861次
张卫群， 王宜人，巢永烈等、类骨质羟磷灰石和自体骨修复兔下颌骨临界性骨缺损的研究、[J].华西口腔医学杂志,2010,7(2):
临界性骨缺损； 类骨质羟磷灰石； 生物相容性； 自体骨
张卫群1，2 王宜人2 巢永烈2
1.山东大学附属省立医院 口腔种植科，山东 济南 250021；2.四川大学华西口腔医院 口腔修复科
2010
知网
目的 探讨类骨质羟磷灰石（SBR）的生物相容性，并探讨该替代材料和自体骨混合修复骨缺损的生物学特性。方法 选用新西兰大白兔，在实验动物双侧下颌骨内侧形成10 mm×10 mm×2 mm大小的临界性缺损，左侧骨缺损按照1∶1比例植入SBR和自体骨，右侧骨缺损内分别植入自体骨或缺如，术后2、4、8周取标本，进行大体标本、X线、组织学和Masson新三色染色法的形态学分析。结果 生物替代物具有良好的生物相容性，与自体骨混合能有效地促进骨缺损的修复愈合。骨髓细胞很容易在该材料表面黏附，自体骨的加入更有利于新骨长入材料的孔隙中，分化增殖，形成骨基质，并钙化成熟。结论 SBR是一种良好的骨替代材料，自体骨的加入更有利于早期成骨和替代材料的自我改建的完成。 Objective After sinboneHT bone replacement （SBR） was implanted in animals, to evaluate the biocom- patibility of SBR and compounded in autogenetic bone in the proportion of one to one in order to prepare for the clinical applications in the future. Methods Bone defects of 10 mm×10 mm×2 mm was made at the mandibular of rabbits, then SBR with different granule diameter and autogenetic bone was compounded in the proportion of being applied in the left defects, while autogenetic bone was implanted in the right defects and nothing was used in the right reformed defects. Animals were sacrificed at 2, 4 and 8 weeks respectively. The biologic capacity was evaluated with anatomy, X-rays studies and histology. Results SBR has better biocompatibility, which can effectively accele- rate the reconstruction of bone defects and help the new bone by being compounded with autogenetic bone. It provides the appropriate scaffold or template which would allow cellular infiltration, attachment and multiplication. Conclusion SBR is a kind of bone substitute material with good biocompatibility. SBR compounded with self-bone has a better regeneration function.
