螺内酯治疗顽固性高血压及对炎性反应因子影响的研究

发表时间：2015-03-31 浏览次数：1359次

引用：

章若涵,马小峰,周翠林.螺内酯治疗顽固性高血压及对炎性反应因子影响的研究[J].吉林医学,2014(19):83-85.

关键词：

作者：

章若涵马小峰周翠林

作者单位：

南华大学附属南华医院心内科,衡阳421001

出版年份：

2014

期刊页数：

83-85

收录者：

知网,万方

摘要：

目的：观察螺内酯治疗顽固性高血压（refractory hypertension,RH）效果的同时,通过观察体内炎症因子高敏C反应蛋白（hs-CRP）、基质金属蛋白酶9（MMP-9）的变化,探讨螺内酯抗动脉硬化、预防心血管事件的作用。方法：选择RH患者,分成对照组及试验组,对照组予三联降压治疗,试验组在三联药物降压基础上加用螺内酯。用药后第3个月、6个月行24 h动态血压测定,同时测定hs-CRP、MMP-9。结果：试验组在治疗后第3个月和第6个月,降压效果显著,hs-CRP、MMP-9水平明显降低,与对照组对比有显著差异（P〈0.05）,这一趋势在第6月更加明显。结论：螺内酯对RH有良好治疗效果,且可控制炎性反应,预防动脉硬化及心血管事件。 Objective We observed the effection of spironolactone＇s anti-resistant hypertension （RH） ,and the variation of inflammatory factors：hs-CRP,MMP-9.We explored the role of spironolac-tone antiarteriosclerosis,and prevented cardiovascular events.Method We selected the RH patients,and they were divided into the control group and the experimental group.Applied the triple antihypertensive therapy in control group,in experimental group,we used spironolactone on the base of triple antihypertensive drugs.Three months and six months later,we estimated the effection of antihypertensive,by 24 hours ambulatory blood pressure measurement,and detected the concentration of hs-CRP,MMP-9.Results 3 months and 6 months later,the antihypertensive effect was significant in experimental group,hs-CRP,MMP-9 levels were declined significantly,compared with the control group,there was significant difference （P〈0.05） ,and this trend was more obvious after 6 months.Conclusion Spironolactone not only has a good effect in treating RH,but also can control the inflammation,prevent atherosclerosis and cardiovascular events.

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