冠心病与血浆脂联素、高敏C-反应蛋白的关系

发表时间：2015-03-27 浏览次数：1397次

引用：

邓应忠,曹晨,郑兴萍等.冠心病与血浆脂联素、高敏C-反应蛋白的关系[J].吉林医学,2014,(19):4182-4184

关键词：

作者：

邓应忠曹晨郑兴萍胡鄂曼

作者单位：

湖北省武汉市第三医院心内科,湖北武汉,430074

出版年份：

2014

期刊页数：

4182-4184

收录者：

知网,万方

摘要：

目的：探讨冠心病患者血浆脂联素、高敏C-反应蛋白的相关性。方法：选择冠心病患者82例，分为急性心肌梗死组22例，不稳定型心绞痛组30例，稳定型心绞痛组30例，正常对照组30例，测定血浆脂联素和高敏C-反应蛋白水平，进行对比分析。结果：冠心病组患者血浆脂联素水平明显降低，且稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组3组血浆脂联素依次降低，各组间差异有统计学意义（ P﹤0.01）；冠心病组患者血浆高敏C-反应蛋白水平明显升高，且稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组3组血浆高敏C-反应蛋白依次升高，各组间差异有统计学意义（ P﹤0.01）。冠心病组患者血浆脂联素水平与高敏C-反应蛋白呈负相关（ r＝0.46，P﹤0.01）。结论：冠心病患者代表抗炎因素的血浆脂联素显著降低，代表炎症活跃的高敏C-反应蛋白显著升高，两者结合应用可以为早期抗炎治疗及对预后判断提供依据。 Objective To investigate the plasma adiponectin in patients with coronary heart disease and high sensitivity C - reactive protein expression and correlation. Method 82 cases of coronary heart disease patients who were chosen,were divided into 22 cases of a-cute myocardial infarction group,30 cases with not stable angina pectoris group,30 cases with stable angina pectoris group and 30 cases of normal group . The determination of plasma plasma adiponectin and high sensitivity C - reactive protein level,were ana-lyzed. Results Plasma adiponectin levels in patients with coronary heart disease group was obviously reduced,and stable angina pectoris,not stable angina pectoris,acute myocardial infarction 3 group serum adiponectin in turn reduce,the difference between groups was statistically significant(P﹤0. 01);Plasma high sensitivity C - reactive protein levels significantly higher,and stable angina pectoris,not stable angina pectoris,acute myocardial infarction 3 group serum high sensitivity C - reactive protein in turn higher,the difference between groups was statistically significant( P﹤0. 01). Conclusion In the patients with coronary heart disease,plasma adiponectin of represents the anti-in-flammatory factors decreased significantly,serum high sensitivity C - reactive protein on behalf of inflammatory activity significant rise,a combination of these applications can be in his early anti-inflammatory treatment and provide a basis for prognostic judgement.

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