平阳霉素联合曲安奈德治疗疤痕疙瘩的疗效观察

发表时间：2014-01-22 浏览次数：1211次

引用：

张萍,陈萍,黎兆军等.平阳霉素联合曲安奈德治疗疤痕疙瘩的疗效观察[J].吉林医学,2013,34(33):6933-6935.

关键词：

平阳霉素；曲安奈德；疤痕疙瘩

作者：

张萍，陈萍，黎兆军，李定

作者单位：

广东医学院附属医院皮肤科，广东湛江 524001

出版年份：

2014

期刊页数：

6933-6935

收录者：

万方

摘要：

目的:评价平阳霉素联合曲安奈德治疗疤痕疙瘩的临床疗效和安全性.方法:将135例疤痕疙瘩患者随机分为A组、B组和C组,每组45例,A组患者采用局部注射平阳霉素及曲安奈德,1次/月,连续1～2次;B组患者局部注射曲安奈德,1次/月,连续1～2次;C组患者局部注射平阳霉素,1次/月,连续1～2次.结果:A组患者治疗后基愈率为62.22％、总有效率为88.89％;B组患者治疗后基愈率为48.89％、总有效率为68.89％;C组患者治疗后基愈率为31.11％、总有效率为64.44％.A组与B组、C组疗效比较,差异均有统计学意义(x 2=5.4040,P=0.0201;x 2=7.5155,P=0.0061);B组与C组疗效比较,差异无统计学意义(x 2=0.2000,P=0.6547).三组患者均无明显不良反应.结论:平阳霉素联合曲安奈德治疗疤痕疙瘩安全、有效. Abstract:Objective To investigate the clinical effect and safety of pingyangmycin combined with triamcinolone acetonide in the treatment of keloids.Methods One hundred and thirty-five outpatients with keloids were divided into group A,B and C randomly.Forty-five patients in group A were treated with local pingyangmycin and triamcinolone acetonide injection once a month for 1 to 2 times.Forty-five patients in group B were treated with triamcinolone acetonide once a month for 1 to 2 times.Forty-five patients in group C were treated with pingyangmycin once a month for 1 to 2 times.Results The results of group A after treatment showed that the cured rate and total effect rate were 62.22% and 88.89%,respectively.The results of group B after treatment showed that the cured rate and total effect rates were 48.89% and 68.89% respectively. The results of group C after treatment showed that the cured rate and total effect rate were 31.11% and 64.44% respectively.The effect rate in group A was significant higher than that of group B and C(χ2 = 5.4040，P＝0.0201；χ2 = 7.5155，P＝0.0061).The effect rate in group B was no statistical significant with group C(χ2 =0.2000,P＝0.6547).Conclusion This investigation indicates that pingyangmycin combined with triamcinolone acetonide are an efficacy and safety therapy in the treatment of keloids.

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