硒结合蛋白1作为肿瘤标志物的研究进展
发表时间:2014-06-23 浏览次数:788次
张晨静,潘驰,潘文胜等.硒结合蛋白1作为肿瘤标志物的研究进展[J].上海交通大学学报(医学版)2013, 33(1).114-117
硒结合蛋白1 个性化指标 抗肿瘤 预测
张晨静,潘驰,潘文胜,陈光兰
(浙江省丽水市人民医院消化内科,丽水,323000)
2013
114-117
知网,万方
硒结合蛋白1(SBP1)共价结合于硒参与多种细胞内硒的转运.然而硒是一种重要的微量元素,与肿瘤的发生有密切联系,是一种新型抗肿瘤物质.近年来随着对SBP1研究的深入,发现其不但可作为预后指导个性化治疗策略的一种新型生物标志物,而且有望成为肿瘤治疗的新靶点并提高肿瘤细胞的化疗敏感性,作为一种新型抗肿瘤治疗策略应用于临床.该文旨在探讨SBP1的抗肿瘤机制及其作为潜在肿瘤标志物的研究进展,以期指导临床肿瘤个性化治疗,提高患者的预后效果. elenium binding plotcin1(sBP1) has been shown to bind selenium covalently and is explessed in a variety of tissues and ccll lines. Seleiium is incorporatcd into selenopr。 teins that havc a lNiide rangc of plciotropic effects, including its important function in prevention of cancer progression Recent studies have revea1ed that SBP1 may not only exert tun1or suppressive function, but a1so bccome a noVcl biomarkcr for predicting prognosis and guiding persona1ized therapeutic strategics This paper bricfly reviews thc studies of sBP1 as a noVel biomarker and tumor suppressor in the progression of various cancers