ID1蛋白在胃癌组织中的表达及临床意义
发表时间：2014-06-19 浏览次数：798次
朱博，宋超，王萍.ID1蛋白在胃癌组织中的表达及临床意义[J].上海交通大学学报（医学版）.2013, 33(3):298-302
胃肿瘤;免疫组织化学;IDI
朱博，宋超，王萍
蚌埠医学院第一附属医院病理科病理学教研室,蚌埠,233004 ；蚌埠医学院第一附属医院胸心外科,蚌埠
2013
298-302
知网,万方
目的 分析人胃癌组织中分化抑制因子1 (ID1)的表达与临床病理参数之间的关系,初步探讨ID1在胃癌发生、发展及患者预后评估中的作用.方法 免疫组织化学EliVision法检测91例胃癌组织、30例正常胃黏膜和35例不典型增生胃黏膜组织中ID1蛋白的表达,分析ID1蛋白表达与胃癌的分化程度、浸润深度、临床TNM分期和淋巴结转移的关系,绘制生存曲线,Log-rank法单因素分析肿瘤临床病理学特征和ID1蛋白的表达与患者预后的关系.结果 免疫组织化学染色结果显示:胃癌组织中ID1蛋白的表达阳性率为63.7％ (58/91),显著高于正常胃黏膜组织(10.0％)和不典型增生胃黏膜组织(42.9％),差异均有统计学意义(P＜0.05).统计学分析结果显示,胃癌组织中ID1蛋白的表达与肿瘤的分化程度、浸润深度、临床TNM分期和淋巴结转移有关(P＜0.05).Log-rank法单因素分析结果显示,肿瘤浸润深度与淋巴结转移与胃癌患者的预后有关(P＜0.05),而与患者年龄、性别及肿瘤直径、大体类型、分化程度、Lauren分型和ID1蛋白的表达等无关(P＞0.05).结论 ID1在胃癌组织中表达异常,可能与胃癌的发生和发展有关,有望为胃癌治疗提供新的治疗靶点,但并非是胃癌患者预后的评估指标. Objective To investigate true relationship between expression of inhibitor of D11A binding/differentiation 1 (1D1)and clinicopathological parameters, and explore the role; of TD1 in the deselopment and prognosis prediction of gastric Methods The expression of 1D1 protein in 91 samples of gastric(ancer tissue:. 30 samples of normal gastric tissues and 35 samples of atypical hypcrplasia gastric tissues was examined by innnnnohistochemical EliVision method. The relationship between expression of ID1 protein and differentiation. invasion. 'f}TMstage and lymph node metastasis of gastric cancer was analysed, the survival curves were山awn, and the correlation of(linicopatholo}ical parameters and expression of TD1 protein with prognosis of patients with gastric cancer man explored with T,og-rank univariate analysis. Results Immunohistochemical staining revealed that the positive rate of c,xpression of 1D1 protein in gastric cancer tissues was 63.7肠 (58/91)，which was significantly higher than those in normal gastric tissues(10. 00l0)and atypical hvperplasia gastric tissues(42.9)(P
