右美托咪定对单肺通气过程中炎性反应及氧化应激反应的影响

发表时间：2014-06-06 浏览次数：1077次

引用：

张伟张加强孟凡民右美托咪定对单肺通气过程中炎性反应及氧化应激反应的影响[J].临床麻醉学杂志,2013,29(03):229-231

关键词：

右美托咪定再灌注损伤单肺通气肺损伤

作者：

张伟张加强孟凡民

作者单位：

河南省人民医院麻醉科,郑州市,450003

出版年份：

2013

期刊页数：

229-231

收录者：

知网,万方

摘要：

探讨右美托咪定对单肺通气(OLV)过程中炎性反应及氧化应激反应的影响.方法择期行食管癌根治术患者40例,ASA Ⅰ或Ⅱ级,年龄45～64岁,体重指数＜30 kg/m2,随机均分为两组:右美托咪定组(D组)和对照组(C组).D组于气管插管后10 min开始静脉输注右美托咪定1 μg/kg(右美托咪定浓度为4μg/ml,输注时间10 min),随后以0.5μg·kg-1 ·h-1持续输注至关胸.C组静脉输注等容量生理盐水作对照.于OLV开始即刻(T0)、OLV后60 min(T1)和术毕(T2)采集肘静脉血,检测丙二醛(MDA)浓度和超氧化物歧化酶(SOD)的水平,酶联免疫法检测TNF-α和IL-6的浓度.结果与T0时比较,T2时两组血清SOD活性降低,MDA、TNF-α和IL-6的浓度升高(P＜0.05)；与C组比较,D组血清SOD活性升高,MDA、TNF-α和IL-6的浓度降低(P＜0.05).结论右美托咪定可抑制单肺通气过程中炎性反应和氧化应激反应,对临床实践中进行肺保护具有积极作用. 　　Effect of dexinedetomidine on inflammatory response and oxidative stress during one-lung ventilationZHANG Wei,ZHANG Jia-qiang,MENG Ean-min .Department of Anesthesiology.Henan ProvincalPeople's Hospital .Zhengzlzou 450003,ChinaCorresponding author:ZHANG Wei,Email:myhope2005@I63.com[Abstract] Objective To observe the effect of dexmedetomidine on inflammatory response andoxidative stress during one-lung ventilation. JZetbods Forty patients,ASA工or } ,aged 45-64,withbody mass index lower than 30 kg'm=.were randomly divided into two groups（}:一20）：　　dexmedetomidine group （group D） and control group（group C），Dexmedetomidine 1 }g/kg wereinfused 10 min after tracheal intubation, followed by continous infusion of dexmedetomidine at rate ofo. 5 ;}g“kg-' ”h-' .Normal saline with equal volume were administrated in group C. Venous bloodsamples were obtained at three time points: the beginning of OI_V, 60 min after （）LV and the end ofoperation. MDA, SOD, TNF-a and IL-6 were detected. Results Compared to T .the activity of SODwere decreased, the plasma concentration o于MDA, TNF-a and工L-6 were increased in both groups at T} 　　（PGO. 05）；Compared to group C, the activity of SOI）were increased in group D, the plasma concentrationof MDA, T'}F-a and II} 6 were decreased at T= CP}O. 05）。 Conclusion Dexmedetomidine could inhibitinflammatory response and oxidative stress during one-lung ventilation in patients udergoing elective resectionof esophageal carcinoma, it has positive effect on the lung protection in clinical process.

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